Beneficial Effects of Triacetyl Azauridine in Psoriasis and Mycosis Fungoides

Article1 February 1966Beneficial Effects of Triacetyl Azauridine in Psoriasis and Mycosis FungoidesPAUL CALABRESI, M.D., RAYMOND W. TURNER, M.D.PAUL CALABRESI, M.D.Search for more papers by this author, RAYMOND W. TURNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-352 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe usefulness of antimetabolites capable of inhibiting nucleic acid biosynthesis has been generally limited by their severe systemic toxicity. Although beneficial effects have been observed in certain neoplastic disorders, the ability of these compounds to inhibit proliferation of all rapidly reproducing tissues often results in marked hematopoietic suppression, stomatitis, gastrointestinal ulcerations, and loss of hair (1). Increased mitotic activity and hyperplasia are also characteristics of the epidermal lesion of psoriasis. Interference with cellular replication by antimetabolites and related antineoplastic agents has achieved beneficial results in psoriasis but not without toxic manifestations due to similar effects in the normal tissues of...References1. CALABRESIWELCH PAD: Chemotherapy of neoplastic diseases. Ann. Rev. Med. 13: 147, 1962. Also in The Pharmacological Basis of Therapeutics, 3rd ed., Section XV, by GOODMAN and GILMAN. The Macmillian Co., New York, 1965, p. 1343. CrossrefMedlineGoogle Scholar2. VAN SCOTTREINERTSON EJRP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis. J. Invest. Derm. 33: 357, 1959. CrossrefMedlineGoogle Scholar3. CALABRESI P: Current status of clinical investigations with 6-azauridine, 5-iodo-2′-deoxyuridine and related derivatives. Cancer Res. 23: 1260, 1963. MedlineGoogle Scholar4. 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Brit. Med. J. 1: 156, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL CALABRESI, M.D.; RAYMOND W. TURNER, M.D.Affiliations: New Haven, ConnecticutFrom the Departments of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Conn.This work was supported in part by grants OG-14, CA-05944, CA-5138, U. S. Public Health Service, Bethesda, Md., and grants from the Burroughs Wellcome Foundation and the Olsen Memorial Fund.Dr. Calabresi is a Burroughs Wellcome Scholar in clinical pharmacology, and Dr. Turner is a U. S. Public Health Service Special Research Fellow supported by grant IF 3-AM-24,279-01.Requests for reprints should be addressed to Paul Calabresi, M.D., Department of Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, Conn. 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BATEMAN, M.D.Triacetyl 6-Azauridine in Mycosis FungoidesPYRIMIDINE METABOLISM AS A TARGET FOR CHEMOTHERAPYCutaneous Manifestations of the Leukemia-Lymphoma GroupChemical Suppression of Adaptive Immunity 1 February 1966Volume 64, Issue 2Page: 352-371KeywordsBiosynthesisClinical pharmacologyDermatologyLesionsMedical servicesNucleic acidsPharmacologyPsoriasisToxicityUlcers ePublished: 1 December 2008 Issue Published: 1 February 1966 PDF downloadLoading ...