Haemophilus influenzae Diphtheria Protein Conjugate Immunization after Therapy in Splenectomized Patients with Hodgkin Disease

Brief Reports15 January 1990Haemophilus influenzae Diphtheria Protein Conjugate Immunization after Therapy in Splenectomized Patients with Hodgkin DiseaseRegina Jakacki, MD, Nicolette Luery, PharmD, Patrick McVerry, PhD, Beverly Lange, MDRegina Jakacki, MDSearch for more papers by this author, Nicolette Luery, PharmDSearch for more papers by this author, Patrick McVerry, PhDSearch for more papers by this author, Beverly Lange, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-143 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with Hodgkin disease are at risk for life-threatening Haemophilus influenzae infections (1, 2). Splenectomy interferes with opsonization and phagocytosis of encapsulated bacteria (3), and chemotherapy and irradiation impair serologic response to polysaccharide antigen (2, 4, 5). Response to protein antigen remains relatively intact (6). The H. influenzae polyribose polysaccharide diphtheria protein-conjugate vaccine has been used to overcome the inability of infants to respond to polysaccharide antigen (7, 8). To determine whether splenectomized patients with Hodgkin disease could also respond we immunized 23 patients with conjugate vaccine.Patients and MethodsTwenty-three patients with Hodgkin disease, 6 to 20 years old...References1. DesserUltmann RJ. Risk of severe infection in patients with Hodgkin's disease or lymphoma after diagnostic laparotomy and splenectomy. Ann Intern Med. 1972;77:143-6. LinkGoogle Scholar2. DonaldsonKaplan SH. Complications of treatment of Hodgkin's disease in children. Cancer Treat Rep. 1982;66:977-89. MedlineGoogle Scholar3. HoseaBrownHamburgerFrank SEMM. Opsonic requirements for intravascular clearance after splenectomy. N Engl J Med. 1981;304:245-50. CrossrefMedlineGoogle Scholar4. WeitzmanAisenbergSiberSmith SAGD. Impaired humoral immunity in treated Hodgkin's disease. N Engl J Med. 1977;297:245-8. CrossrefMedlineGoogle Scholar5. SiberGorhamMartinCorkerySchiffman GCPJG. Anti-body response to pretreatment immunization and post-treatment boosting with bacterial polysaccharide vaccines in patients with Hodgkin's disease. Ann Intern Med. 1986;104:467-75. LinkGoogle Scholar6. SiberWeitzmanAisenberg GSA. Antibody response of patients with Hodgkin's disease to protein and polysaccharide antigens. Rev Infect Dis. 1981;3(Suppl):S144-59. CrossrefMedlineGoogle Scholar7. EskolaPeltolaTakala JHA. Efficacy of Haemophilus influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine in infancy. N Engl J Med. 1987;817:717-22. CrossrefGoogle Scholar8. LepowRandolphCimma MMR. Persistence of antibody and response to booster dose of Haemophilus influenzae type b polysaccharide diphtheria toxoid conjugate vaccine in infants immunized at 9 to 15 months of age. J Pediatr. 1986;108:882-6. CrossrefMedlineGoogle Scholar9. LangeLittman BP. Management of Hodgkin's disease in children and adolescents. Cancer. 1983;51:1371-7. CrossrefMedlineGoogle Scholar10. KahytyPeltolaKarankoMakela HHVP. The protective level of serum antibodies to the capsular polysaccharide of Hemaphilus influenzae type b. J Infect Dis. 1983;147:1100. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Wyeth-Ayerst Laboratories, Radnor, Pennsylvania; and Connaught Laboratories, Swiftwater, Pennsylvania. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHaemophilus influenzae type b (Hib) vaccineVACCINESSurgical Infection Society Guidelines for Vaccination after Traumatic InjuryHaemophilus influenzae type b (Hib) vaccineImmunization Recommendations for Adults with CancerHaemophilus influenzaeCritical Appraisal of Immunization Strategies for Prevention of Infection in the Compromised HostInvasive Haemophilus influenzae Disease in Adults A Prospective, Population-based SurveillanceMonica M. Farley, MD, David S. Stephens, MD, Philip S. Brachman Jr., MD, R. Christopher Harvey, MPH, J. David Smith, BS, Jay D. Wenger, MD, CDC Meningitis Surveillance GroupAntibody Response to a Haemophilus influenzae Type b Polysaccharide Tetanus Toxoid Conjugate Vaccine in Splenectomized Children and AdolescentsImmunobiological preparations 15 January 1990Volume 112, Issue 2Page: 143-144KeywordsAntigensChildrenDiphtheriaHaemophilus influenzaeHematology and oncologyHodgkin lymphomaPolysaccharidesProteinsSplenectomyVaccines Issue Published: 15 January 1990 PDF DownloadLoading ...