The mechanism of the chemiluminescence emitted during phagocytosis of opsonized zymosan was investigated. The use of an artificial system generating singlet oxygen permitted the distinction between the respective roles of O 2 and HOCl in the light production via the reactions with opsonized zymosan, amino‐acids and peptides. The reaction of free hypochlorous acid, produced by the myeloperoxidase H 2 O 2 ‐Cl‐ system, with free tryptophan appears to be a likely path for the production of chemiluminescence. Implications for the mechanism of in vivo chemiluminescence during phagocytosis are considered.
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Violet et al. (1984) studied this question.
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