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June 1, 1999Cardiovascular ResearchOpen Access

Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo

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Why the study?

Does OPC-6535 prevent cytokine-induced myocardial dysfunction in a canine model?

Population

Mongrel dogs subjected to intracoronary injection of microspheres with interleukin-1 beta to induce…

Comparison

OPC-6535 2 mg/kg i.v. before and 1 mg/kg i.v. at… vs Control microspheres without IL-1 beta, and IL-1…

Design

Preclinical

Follow-up

1 week

Discussion

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Implication

Supports superoxide inhibition against cytokine-mediated dysfunction in vivo; leaves open translation to human inflammatory cardiomyopathy.

Structured PICO

Does OPC-6535 prevent cytokine-induced myocardial dysfunction in a canine model?

P
Population
Mongrel dogs subjected to intracoronary injection of microspheres with interleukin-1 beta (IL-1 beta) to induce myocardial dysfunction
I
Intervention
OPC-6535 (inhibitor of superoxide production) 2 mg/kg i.v. before and 1 mg/kg i.v. at 1 and 2 days after IL-1 beta application
C
Comparator
Control microspheres without IL-1 beta, and IL-1 beta microspheres without OPC-6535
O
Outcome
Left ventricular ejection fraction (LVEF) evaluated by echocardiography over 1 weeksurrogate

Superoxide anion and peroxynitrite formation are involved in the pathogenesis of cytokine-induced myocardial dysfunction in vivo, which can be prevented by a superoxide production inhibitor.

Cite This Study

A 1999 study studied this question.

synapsesocial.com/papers/6a7dd8c1c108c8d3ff045c64https://doi.org/10.1016/s0008-6363(98)00317-4

Topics

Echocardiography
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.1994 · 218 citations
  2. 2Increased superoxide anion release from human endothelial cells in response to cytokines.1986 · 363 citations
  3. 3Mechanism of myocardial "stunning".1990 · 993 citations
  4. 4Reperfusion-induced arrhythmias and oxygen-derived free radicals. Studies with "anti-free radical" interventions and a free radical-generating system in the isolated perfused rat heart.1986 · 393 citations