Why the study?
Do buccal mucosa cells from arrhythmogenic cardiomyopathy patients exhibit abnormal distribution of cell junction proteins that can be reversed by SB216763?
Do buccal mucosa cells from arrhythmogenic cardiomyopathy patients exhibit abnormal distribution of cell junction proteins that can be reversed by SB216763?
Buccal mucosa cells can serve as a non-invasive surrogate tissue to study the molecular pathology of arrhythmogenic cardiomyopathy and screen potential therapies.
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May enable non-invasive surrogate tissue studies in arrhythmogenic cardiomyopathy; leaves open therapeutic translation of SB216763.
Asimaki et al. (2016) studied this question.
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