presenting with the severe form of this ill- ness, as described above.Surgery should be avoided,' 2 as the majority of cases described have improved with supportive treatmente-3 together with systemic and/or local steroids and more recently cholestyramine.4A firm diagnosis can usually be made at sigmoido- scopy and rectal biopsy, thereby distinguishing it from acute ulcerative colitis, which the barium enema cannot do.5Clindamycin-associated pseudomembranous colitis is now well described.Estimates of the incidence in patients taking this drug vary from 000001 % 2 to 10% .3As this ill- ness may be severe, protracted, and life- threatening we wish to make a plea that this antibiotic be used only for severe anaerobic infections such as bacteroides septicaemia.We feel that its activity against Gram- positive infections does not justify its use against these organisms as the drug of choice.-Weare, etc.,
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Matthew Prior (1975) studied this question.
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