Pd-Catalyzed Asymmetric Allylic Alkylations of 3-Substituted Indoles Using Chiral P/Olefin Ligands

A palladium-catalyzed asymmetric allylic alkylation of 3-substituted indoles using P/olefin ligands was successfully achieved to afford a variety of indolenines containing a quaternary carbon stereocenter in high yields with up to 87% ee. Significantly, this reaction provides a concise access to a stereoisomer of the natural product Angelicastigmin.