Enantioselective Modular Synthesis of 2,4‐Disubstituted Cyclopentenones by Iridium‐Catalyzed Allylic Alkylation

Classy combo: Together, the asymmetric iridium-catalyzed allylic alkylation and ruthenium-catalyzed ring-closing metathesis lead to an efficient synthesis of chiral cyclopentenones (see scheme). One example is the synthesis of the antitumor agent TEI-9826 with high enantiomeric purity.