May 22, 2007Biochemical Society Transactions

Chylomicron and apoB48 metabolism in the JCR:LA corpulent rat, a model for the metabolic syndrome

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Population

JCR:LA-cp rat model (obese phenotype and lean controls)

Design

Review

Authors

RMRabban MangatWest Park Healthcare Centre JSJenny SuAustralian Centre for Disease Preparedness PSPaul G. ScottNaval Medical Center Portsmouth

Discussion

Member takes

Implication

Supports JCR:LA-cp rat as model for postprandial dyslipidemia in metabolic syndrome; leaves open translation to clinical practice.

Structured PICO

Population

JCR:LA-cp rat model (obese phenotype and lean controls)

Outcome

Chylomicron and apoB48 metabolism, postprandial lipaemia, and vascular remodelingsurrogate

The JCR:LA-cp rat is a useful preclinical model for studying postprandial dyslipidemia and pro-atherogenic vascular remodeling in the context of metabolic syndrome and insulin resistance.

Cite This Study

Mangat et al. (2007) studied this question.

synapsesocial.com/papers/6a7df0d633dcb27c99cb6210 https://doi.org/10.1042/bst0350477

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