A Model for Chromatin Remodeling by the SWI/SNF Family

During the past few years, our knowledge of how chromatin structure can be made more accessible to transcription and other reactions on the DNA has grown rapidly.One prominent mechanism for increasing access to DNAin chromatin is via remodeling of chromatin structure byATP-dependent processes. A wide variety of ATP-dependent nucleosome remodeling complexes have beenidentified. Each of these contains a homolog to the yeastSWI2/SNF2 ATPase and has been shown to alter thestructure of chromatin in vitro...