Lost in transmetalation: The titanium(IV)-catalyzed title reaction, utilizing chiral cinchona alkaloids as ligands (L1 and L2), was developed for the synthesis of both enantiomers of trifluoromethylated propargylic tertiary alcohols in high yield and enantioselectivity. Small amounts of BaF2 were found to be essential for maintaining high levels of reactivity and enantioselectivity.
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Zhang et al. (2011) studied this question.
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