Why the study?
Does the expression of inflammatory and oxidative stress markers in the internal mammary artery graft differ between diabetic and non-diabetic patients undergoing CABG?
Does the expression of inflammatory and oxidative stress markers in the internal mammary artery graft differ between diabetic and non-diabetic patients undergoing CABG?
This research proposal aims to investigate differences in inflammation and oxidative stress in internal mammary artery grafts between diabetic and non-diabetic patients undergoing CABG.
No immediate change to CABG graft selection in diabetes; leaves open whether IMA inflammation differs by diabetic status.
BACKGROUND: Diabetes mellitus patients (DM) have more severe progression of atherosclerotic disease than non-diabetic (NDM) individuals. In situ inflammation and oxidative stress are key points in the pathophysiology of atherosclerosis, a concept largely based on animal model research. There are few studies comparing inflammation and oxidative stress parameters in medium-sized arteries between DM and NDM patients. A fragment of the internal mammary artery used in coronary artery bypass grafting (CABG) will be employed for this purpose OBJECTIVE: To assess the expression of inflammatory markers tumor necrosis factor-α, transforming growth factor-β1, nuclear factor kappa B, the enzymes superoxide dismutase, and catalase in the vascular wall of the arterial graft used in CABG, comparing DM and NDM patients RESULTS: The present study will add information to the vascular degenerative processes occurring in diabetic patients.
No takes yet. Share an insight, caveat, or question.
Silva et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: