Why the study?
Does single antiplatelet therapy plus warfarin improve safety or efficacy compared to dual antiplatelet therapy plus warfarin in patients with acute coronary syndrome undergoing coronary stenting?
Population
800 patients with an acute coronary syndrome who underwent coronary stenting and were discharged on warfarin.
Comparison
Single antiplatelet therapy plus warfarin vs Dual antiplatelet therapy plus warfarin
Design
Cohort
Follow-up
6 months
Authors
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Similar outcomes with single versus dual antiplatelet therapy plus warfarin; hypothesis-generating and should not change practice without randomized confirmation.
Does single antiplatelet therapy plus warfarin improve safety or efficacy compared to dual antiplatelet therapy plus warfarin in patients with acute coronary syndrome undergoing coronary stenting?
In patients with acute coronary syndrome undergoing stenting and requiring warfarin, single antiplatelet therapy appears to have similar 6-month outcomes to dual antiplatelet therapy, though larger randomized trials are needed.
Nguyen et al. (2007) studied this question.
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