Acute experimental pancreatitis was induced in dogs by injection of a mixture of cholates and trypsin into the main pancreatic duct. Exudate was collected directly from pancreas at various time intervals after induction of the ailment. The exudate produced early during the ailment contained large amounts of cholates, whereas that produced late contained only small amounts. All exudate portions were found to contain phosphatidyl-choline-hydrolyzing activity. The major part of this activity was due to phospholipase A. The influence of cholates on the phosphatidyl-choline-hydrolyzing activity of the exudate is discussed.
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Hagen et al. (1969) studied this question.
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