What question did this study set out to answer?

To examine the interplay between glymphatic clearance, white matter structural network efficiency, and cognitive function in individuals with primary insomnia.

November 19, 2025Brain Research BulletinOpen Access

Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: A DTI-ALPS mediation study

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Authors

CWChen WangXijing Hospital TZTian ZhangWenzhou Medical University HLHuizhen LuAnhui Agricultural University

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Implication

Case-control study reveals that glymphatic clearance deficits disrupt white matter network efficiency in primary insomnia, indicating a structural pathway to attention decline.

Key Points

To examine the interplay between glymphatic clearance, white matter structural network efficiency, and cognitive function in individuals with primary insomnia.
Assessed 36 patients with primary insomnia and 36 matched healthy controls using diffusion tensor imaging (DTI).
Quantified glymphatic activity via the DTI-ALPS index, mapped structural white matter networks using probabilistic tractography and graph theory, and evaluated sustained attention via the Psychomotor Vigilance Task (PVT).
Performed group comparisons, partial correlation analyses, and mediation analyses linking sleep quality (PSQI), glymphatic function, network metrics, and cognitive performance.
Primary insomnia patients showed a significantly lower DTI-ALPS index (1.24 ± 0.18 vs. 1.41 ± 0.17; p = 0.003; Bonferroni-corrected p = 0.036), prolonged PVT reaction times (445.89 ± 67.62 ms vs. 405.17 ± 61.32 ms; p = 0.009), and higher PSQI scores (12.78 ± 3.70 vs. 2.72 ± 1.34; p < 0.001).
The DTI-ALPS index correlated positively with structural global network efficiency and negatively with PSQI scores and PVT reaction times.
Mediation analyses showed that glymphatic activity mediated the effect of poor sleep on network efficiency, and network efficiency mediated the link between glymphatic function and sustained attention.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6a7e01b1699b737ada99a466 https://doi.org/10.1016/j.brainresbull.2025.111640

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Implication

Case-control study reveals that glymphatic clearance deficits disrupt white matter network efficiency in primary insomnia, indicating a structural pathway to attention decline.

Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: A DTI-ALPS mediation study

Discussion

Member takes

Implication

Key Points

Cite This Study

Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: A DTI-ALPS mediation study

Discussion

Member takes

Implication

Key Points

Cite This Study

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