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December 1, 2008The Journal of ImmunologyOpen Access

Mycobacterium tuberculosis-Specific CD8+ T Cells Require Perforin to Kill Target Cells and Provide Protection In Vivo

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Authors

JWJoshua S. WoodworthStatens Serum InstitutYWYing WuJohns Hopkins UniversitySBSamuel M. BeharUniversity of Massachusetts Chan Medical School

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Woodworth et al. (2008) studied this question.

synapsesocial.com/papers/6a7e01e77bc3bc414599ba5ahttps://doi.org/10.4049/jimmunol.181.12.8595
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of in vitro models for the study of Mycobacterium tuberculosis invasion and intracellular replication1996 · 165 citations
  2. 2Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein2005 · 52 citations
  3. 3CD8+ CTL from Lungs of Mycobacterium tuberculosis -Infected Mice Express Perforin In Vivo and Lyse Infected Macrophages2000 · 166 citations
  4. 4Next generation: tuberculosis vaccines that elicit protective CD8+T cells2007 · 52 citations
  5. 5Identification and Characterization of Murine Cytotoxic T Cells That KillMycobacterium tuberculosis2000 · 90 citations