Total Synthesis of Theopederin D

The transformation is complete! The total synthesis of theopederin D (see structure), a potent cytotoxin, has been achieved through oxidative cleavage of a carbon–carbon bond. Other key transformations include an acid-mediated functionalization of a tetrahydrofuranol, a syn-selective glycal epoxide ring-opening, and an asymmetric aldehyde/acid chloride condensation.