Why the study?
Does tissue Doppler imaging detect intraventricular asynchrony in subjects with isolated left bundle branch block compared to healthy controls?
Does tissue Doppler imaging detect intraventricular asynchrony in subjects with isolated left bundle branch block compared to healthy controls?
Tissue Doppler imaging demonstrates intraventricular asynchrony in isolated LBBB, which may contribute to decreased global ejection fraction.
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Supports TDI detection of asynchrony in isolated LBBB; hypothesis-generating for contribution to reduced EF.
BACKGROUND: The aim of this study was to evaluate normal subjects with isolated left bundle branch block (LBBB) using tissue Doppler imaging (TDI) for the presence of intraventricular asynchrony. METHODS AND RESULTS: For this purpose, 23 subjects with isolated LBBB were compared with age-matched asymptomatic healthy subjects without LBBB with respect to global ejection fraction (EF) and isovolumic contraction time (ICTm) in separate left ventricular segments. TDI evaluation revealed prolongation of the ICTm in all of the segments in the LBBB group. Moreover, the ICTm differed significantly in each segment in the LBBB group. The ICTm in the lateral segments were shown to be longer compared to the anteroseptal segments. CONCLUSION: Our results indicate the presence of intraventricular asynchrony in isolated LBBB. This fact may play a role in the decreased global EF and increased cardiac mortality in patients with isolated LBBB.
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Melek et al. (2006) studied this question.
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