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The present study has demonstrated that urea is present in gingival crevicular fluid and its concentration is usually several times higher than that of blood serum or saliva. This supports the hypothesis that the high pH seen in gingival crevices arises from urea. The concentration of crevicular urea was inversely related to the severity of gingival inflammation and increased markedly following periodontal surgery. It was concluded that clinically healthy or slightly inflamed gingivae have a mechanism for concentrating urea in crevicular fluid and that this mechanism is destroyed during inflammation but reconstituted following periodontal surgery.
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Golub et al. (1971) studied this question.
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