Migration of lymphocytes into hepatic sinusoids

Fig. 1. (A) Receptor–ligand pairs directing cells to the liver. Vascular Adhesion Protein-1 (VAP-1) is an adhesion molecule, prominent on hepatic endothelium, that promotes the liver localization of NK cells, CD8+ T cells and CD4+ T cells of the Th2 subset [1,2]. VAP-1 binds to Sialic Acid-binding Immunoglobulin-like Lectin (Siglec) molecules; T cell and NK cell adhesion acts via Siglec-10, while granulocyte adhesion to VAP-1 is mediated by Siglec-9 [3,4], as well as the interaction of CD44 with hyaluronan [5].