Thinking outside the box: A newly developed C1-symmetric Rh/Phebox complex efficiently catalyzed the asymmetric alkynylation of α-ketoester 1 with various aryl and alkyl substituted terminal alkynes to provide the corresponding chiral tertiary propargylic alcohols with up to 99 % ee (see scheme; TMS=trimethylsilyl).
No takes yet. Share an insight, caveat, or question.
Ohshima et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: