Why the study?
What are the principles of volume therapy and the role of different synthetic colloids as plasma substitutes in surgical and cardiac surgery patients?
What are the principles of volume therapy and the role of different synthetic colloids as plasma substitutes in surgical and cardiac surgery patients?
This review outlines the principles of perioperative volume therapy and evaluates the use of synthetic colloids in surgical and cardiac surgery patients.
Conflicting meta-analyses leave optimal synthetic colloid choice unresolved in cardiac surgery; further RCTs needed before practice change.
SUMMARY Adequate volume replacement is known to be a therapeutic cornerstone in the perioperative period. Guarantee or/of restoration of tissue perfusion represents a particular challenge in patients with circulatory abnormalities. Besides the natural colloid albumin and crystalloids, synthetic colloids such as gelatins, dextrans or hydroxethyl starch (HES) preparations are used in this situation. Meta‐analyses have shown conflicting results and appear to be more confusing than helpful in evaluating the ‘ideal’ kind of solution for volume therapy. The principles of volume therapy in the surgical and cardiac surgery patient are presented and the different synthetic colloids as plasma substitutes are reviewed.
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Joachim Boldt (1999) studied this question.
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