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July 31, 2026Dermatology Practical & ConceptualOpen Access

Dermatoscopic Assessment of Nail Fold Capillary Patterns in Patients of Color with Different Autoimmune Connective Tissue Diseases

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Authors

EAEman AyeshaSHSumera HanifMTMadeline Tchack

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Overview

Cross-sectional study reveals significant links between dermatoscopic nail fold capillary patterns and disease severity in patients of color, indicating capillaroscopy's value as a biomarker.

Key Points

  • To characterize nail fold capillary patterns via handheld dermatoscopy and evaluate their association with disease severity in patients of color with autoimmune connective tissue diseases.
  • Conducted a six-month cross-sectional study at Ghurki Trust Teaching Hospital in Lahore, Pakistan.
  • Evaluated 96 patients with Fitzpatrick skin types IV–VI diagnosed with autoimmune connective tissue diseases using a HEINE DELTA 30 dermatoscope alongside clinical disease activity scoring.
  • Normal capillary patterns appeared in 28.1% (n=27), nonspecific patterns in 29.2% (n=28), and scleroderma patterns in 42.7% (n=41) of participants, with scleroderma patterns appearing most frequently in systemic scleroderma and systemic lupus erythematosus.
  • The most prevalent microvascular changes were focal microhemorrhages (52.1%) and discrete devascularization (50.0%).
  • Capillary morphology varied significantly across disease durations (p = 0.001) and showed a statistically significant association with clinical disease severity (p < 0.001).

Cite This Study

Ayesha et al. (2026) studied this question.

synapsesocial.com/papers/6a7e19df77f4a069369bedfehttps://doi.org/10.5826/dpc.1603a6840
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dermatoscopic Assessment of Nailfold Capillary Structures in Connective Tissue Diseases2024
  2. 2Nail involvement in connective tissue diseases: an epidemiological, clinical, and dermoscopic study2024 · 2 citations
  3. 3Association of nailfold capillaroscopic findings with clinical features in patients with systemic sclerosis2024 · 2 citations
  4. 4Will different nailfold capillaroscopic patterns in autoimmune rheumatic patients be a future tool for early detection of coronary microvascular dysfunction? A prospective cohort study2025
  5. 5Nailfold Capillary Changes in Adult Bangladeshi Patients with Systemic Lupus Erythematosus: Correlation with Disease Activity2024