Answers are grounded in this paper and cite their sources.
Hindered chiral ethers with one or two stereocenters are now readily available by allylic etherification of primary and secondary alkoxides (see reaction). When an Ir–phosphoramidite complex is used as the catalyst, the reaction proceeds with high regio-, enantio-, and diastereoselectivity. Np=1-naphthyl.
No takes yet. Share an insight, caveat, or question.
Shu et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: