Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN₃, and Ethers: Regiocontrollable Synthesis of N¹- and N²-Oxyalkylated 1,2,3-Triazoles

A new copper-catalyzed selective synthesis of N 1 - and N 2 -oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction of alkynes, TMSN 3, and ethers. Through this methodology, a series of N 1 - and N 2 -oxyalkylated 1,2,3-triazoles could be efficiently and regioselectively obtained from simple and readily available starting materials with favorable functional group tolerance.