Why the study?
Does ABT-870 prevent infusion-related hypotension compared to iron sucrose and sodium ferric gluconate complex in anaesthetized dogs?
Population
Anaesthetized dogs
Comparison
ABT-870 (iron--hydroxide-oligosaccharide)… vs Iron sucrose and sodium ferric gluconate complex
Design
Preclinical
Authors
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May allow higher-dose iron delivery without hypotension in dogs; leaves open human translation and trials.
Does ABT-870 prevent infusion-related hypotension compared to iron sucrose and sodium ferric gluconate complex in anaesthetized dogs?
ABT-870 can be administered at high doses and rapid infusion rates without causing the dose-limiting hypotension seen with other parenteral iron therapies in a canine model.
Liu et al. (2005) studied this question.
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