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Various factors unique to elderly patients such as physical, physiological, psychological, and socioeconomic factors affect the outcome of dermatophytic infection and its management. The associated comorbidities such as renal and hepatic failure and polypharmacy influence the pharmacological properties of antifungal agents. These drugs are potent inhibitors of hepatic enzymes involved in drug metabolism leading to accumulation and subsequent toxicity of various classes of drugs. All these factors are considered in the management of dermatophytosis in elderly especially with comorbidities.
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Ragunatha et al. (2017) studied this question.
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