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August 17, 2018Experimental and Therapeutic MedicineOpen Access

Nrf2‑dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin‑induced cardiotoxicity

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Why the study?

Does Tanshinone IIA prevent doxorubicin-induced cardiotoxicity in preclinical models?

Population

30 male Institute of Cancer Research mice (aged 6 weeks, weighing 25-29 g) and H9c2 rat myoblast cells.

Comparison

Tanshinone IIA + Doxorubicin in mice; Tanshinone… vs Doxorubicin alone and normal saline control.

Design

Preclinical, The mice were randomly assigned to 5 groups

Follow-up

8 days (in vivo)

Authors

ZGZhaohui GuoHunan Institute of MicrobiologyMYMiao YanMinistry of Education of the People's Republic of ChinaLCLei ChenThe Ohio State University

Discussion

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Overview

Hypothesis-generating for Tanshinone IIA cardioprotection; human trials needed before clinical consideration.

Structured PICO

Does Tanshinone IIA prevent doxorubicin-induced cardiotoxicity in preclinical models?

P
Population
30 male Institute of Cancer Research mice (aged 6 weeks, weighing 25-29 g) and H9c2 rat myoblast cells.
I
Intervention
Tanshinone IIA (15 or 30 mg/kg intraperitoneal days 1-7) + Doxorubicin (18 mg/kg intraperitoneal day 5) in mice; Tanshinone IIA (1-10 µM for 4h) + Doxorubicin (1 µM for 24h) in H9c2 cells.
C
Comparator
Doxorubicin alone (18 mg/kg in mice; 1 µM in cells) and normal saline control.
O
Outcome
Myocardial injury assessed by serum myocardial enzymes (AST, LDH, CK, CK-MB).surrogate

Tanshinone IIA mitigates doxorubicin-induced cardiotoxicity in preclinical models by activating the Nrf2-dependent antioxidant pathway.

Cite This Study

Guo et al. (2018) studied this question.

synapsesocial.com/papers/6a7e280474ee1427e1960461https://doi.org/10.3892/etm.2018.6614
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Also Consider

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