Thrombospondin-1 and Angiotensin II inhibit soluble guanylyl cyclase by increasing intracellular calcium, revealing a mechanistic balance between vasodilation and vasoconstriction signals.
No takes yet. Share an insight, caveat, or question.
TSP-1/Ang II may inhibit sGC via calcium in animals; extends mechanistic insight into vascular tone balance but leaves clinical relevance open.
Ramanathan et al. (2011) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: