Why the study?
The exact etiology of peripartum cardiomyopathy remains unknown, although recent studies suggest angiogenic imbalance may play a key factor.
This review summarizes the epidemiology, risk factors, diagnosis, treatment, and prognosis of peripartum cardiomyopathy, highlighting the emerging role of angiogenic imbalance in its etiology.
Peripartum cardiomyopathy (PPCM) is a disorder in which heart failure develops in the last month of pregnancy or within the first five months postpartum. The exact etiology is not known although recent studies suggest angiogenic imbalance is a key factor with soluble fms-like tyrosine kinase-1 (sFlt1) and a cleaved form of prolactin possibly playing important roles. This review discusses the epidemiology, risk factors, diagnosis, treatment and prognosis of PPCM and highlights recent advances in our understanding of this disorder.
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Yaranov et al. (2019) studied this question.
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