Why the study?
The study examined the association between arterial stiffness measured by non-invasive pulse wave velocity and cerebrospinal fluid Alzheimer's disease biomarkers.
Is high pulse wave velocity associated with Alzheimer's disease cerebrospinal fluid biomarker positivity?
Is high pulse wave velocity associated with Alzheimer's disease cerebrospinal fluid biomarker positivity?
Higher arterial stiffness, measured by pulse wave velocity, is associated with Alzheimer's disease cerebrospinal fluid biomarker positivity.
High PWV may flag AD biomarker risk; hypothesis-generating and should not yet change practice.
We examined the association between arterial stiffness using non-invasive pulse wave velocity (PWV) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. We conducted a cross-sectional multivariate logistic regression analysis using established cut-off values for PWV and CSF biomarkers. Of the 739 participants, 69% were female, 84% were White, 12% were Black, and the mean age was 62. After adjustment for potential confounders, participants with high PWV had 94% (OR = 1.94, 95% CI 1.20–3.20) greater odds of AD biomarker positivity for tTau/Aβ 42 and 108% (OR = 2.08, 95% Cl, 1.27–3.46) for pTau181/Aβ 42 . Our results suggest that higher arterial stiffness is associated with AD CSF biomarker positivity.
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Kulshreshtha et al. (2025) studied this question.
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