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December 1, 1978British Journal of PharmacologyOpen Access

Effects of Sulphinpyrazone and Aspirin on Prostaglandin I2 (Prostacyclin) Synthesis by Endothelial Cells

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Population

Cultured endothelial cells

Design

Preclinical

Follow-up

24 hours

Authors

JGJohn L. GordonQatar Petroleum (Qatar)JPJeremy D. PearsonKing's College London

Discussion

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Implication

Highlights aspirin's greater endothelial potency versus sulphinpyrazone in animal models; leaves open translation to human cardiovascular therapy.

Structured PICO

P
Population
Cultured endothelial cells
I
Intervention
Aspirin (100 mumol/l and 1 mmol/l) and sulphinpyrazone
O
Outcome
Synthesis of prostaglandin I2 (prostacyclin) assayed by the ability to inhibit platelet aggregationsurrogate

Aspirin potently inhibits endothelial prostacyclin synthesis with dose-dependent recovery, whereas sulphinpyrazone is significantly less potent and has a transient effect.

Cite This Study

Gordon et al. (1978) studied this question.

synapsesocial.com/papers/6a7e35bbef8e9536aa856242https://doi.org/10.1111/j.1476-5381.1978.tb17308.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acetylation of prostaglandin synthase by aspirin.1975 · 1,014 citations
  2. 2Sulfinpyrazone in the Prevention of Cardiac Death after Myocardial Infarction1978 · 299 citations
  3. 3A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction1974 · 519 citations