Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study

Aim: Fasting glucose has been associated with vascular aging, but the association between HbA1c and vascular aging has been limitedly studied in Chinese and other ethnic populations. We aimed to examine this association in a large sample of Chinese adults. Methods: In the Tianning Cohort (N=5142), fasting glucose, HbA1c, carotid-femoral pulse wave velocity (cfPWV), and pulse pressure (PP) were measured. Vascular aging was defined as having the highest quartile level of cfPWV or PP. We applied quantile regression models to examine the association between glucose metabolism and vascular aging. Results: The median cfPWV was significantly increased as increasing quintiles of fasting glucose (β=0.14, P <0.001) and HbA1c (β=0.07, P =0.0056), respectively. Per 1-mmol/L increment of fasting glucose was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.05, P =0.022), PP (OR=1.06, P =0.048), or either (OR=1.08, P =0.002). Similarly, per 1% increment of HbA1c was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.06, P =0.044), PP (OR=1.10, P =0.012), or either (OR=1.12, P =0.042). Conclusion: Glucose metabolism was significantly and positively associated with vascular aging in Chinese adults, but the causality is uncertain.