Intracranial Hypertension and Minocycline

Letters15 July 1997Intracranial Hypertension and MinocyclineJoseph Shiri, MD and Boaz Amichai, MDJoseph Shiri, MDTel-Nordoy Clinic; Tel-Aviv, Israel and Boaz Amichai, MDTel-Nordoy Clinic; Tel-Aviv, IsraelAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report a case of intracranial hypertension with permanent visual damage after minocycline treatment.A 19-year-old healthy woman was treated with minocycline, 100 mg/d, for acne vulgaris. Two weeks after treatment began, the patient presented with severe headache, nausea, and visual disturbance. Ophthalmologic examination revealed severe bilateral papilledema with visual field damage. A computed tomographic scan of the brain was normal. After minocycline therapy was discontinued and acetazolamide was administered, the papilledema disappeared. However, the patient's visual fields and visual acuity are permanently damaged.Tetracyclines, especially minocycline, are widely used to treat acne vulgaris. Despite the listed ...References1. Lubetzki C, Sanson M, Cohen D, et al. Benign intracranial hypertension and minocycline. Rev Neurol Paris. 1988; 144:218-20. Google Scholar2. Delaney RA, Narayanswamy TR, Wee D. Pscudo-tumor cerebri and acne. Mil Med. 1990:155:511. Google Scholar3. Le-Bris P, Glacet-Breard A, Coscas G, et al. Papilledema caused by minocycline: apropos of a case. J Fr Ophthalmol. 1988:11:681-4. Google Scholar4. Lander CM. Minocycline-induced benign intracranial hypertension. Clin Exp Neurol. 1989; 26:161-7. Google Scholar5. Donnet A, Dufour H, Graziani N, et al. Minocycline and benign intracranial hypertension. Biomed Pharmacother. 1992; 46:171-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tel-Nordoy Clinic; Tel-Aviv, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDapsone, penicillamine, thalidomide, bucillamine, and the tetracyclinesSide Effects of Minocycline Treatment in Patients With Fragile X Syndrome and Exploration of Outcome MeasuresWhat is New About Idiopathic Intracranial Hypertension? An Updated Review of Mechanism and TreatmentSafety of doxycycline and minocycline: A systematic reviewCyclines et acné : attention aux effets indésirables ! Aspects récents de la littératureTetracyclines for the treatment of rheumatoid arthritisComplications of Minocycline Therapy for Acne Vulgaris: Case Reports and Review of the LiteraturePenicillins, cephalosporins, other β-lactam antibiotics, and tetracyclinesMINOCYCLINE FOR THE TREATMENT OF RHEUMATOID ARTHRITIS 15 July 1997Volume 127, Issue 2Page: 168KeywordsAcneHeadachesHypertensionInfantsNauseaPatientsRetinoidsSigns and symptomsTetracyclinesVisual acuity Issue Published: 15 July 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...