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SummaryThe results of penicillin sensitivity tests for staphylococci are influenced by the size of the inoculum on two accounts: (a) the presence in sensitive strains of a minority of resistant individuals originating by mutation; and (b) the occurrence of penicillinase-producing strains whose cells are individually sensitive to penicillin. A simple laboratory test is proposed for the detection and quantitative measurement of penicillin resistance in staphylococcus.
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S. E. Luria (1946) studied this question.
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