Role and Molecular Mechanisms of Lysosomes and Cathepsins in Neuropathology and Aging: New Insights

Lysosomes are the major catabolic machinery that degrades several biomolecules and pathogens. They do so by a vast assortment of their cathepsins and help in maintaining homeostasis. Cathepsins and their variants are reported to be involved in multiple physiological activities including apoptosis, coagulation, cell proliferation, immunity, and digestion, etc. Here, we have reviewed the role of lysosomes and cathepsins in various nervous system pathologies and aging. Moreover, we have provided an insightful approach that by targeting these cathepsins may promise better future therapies to improve not only the life span but also the healthspan.