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Discusses the biological role of corin and its potential as a circulating biomarker in acute and chronic myocardial infarction.
In the heart, corin is a membrane-anchored, serine protease that cleaves and activates pro-ANP and pro-BNP, thereby modulating salt-water balance, vasodilatation and cardiac function (1). Cardiac corin can also be released from cardiomyocyte membranes and enter the circulation as a soluble form, where it can readily be measured in the blood.
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Wang et al. (2017) studied this question.
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