A direct defluorinative multifluoroarylation of unactivated sp 3 C–H bonds through hydrogen atom transfer using photoredox catalysis has been developed. The C(sp 3 )–C(sp 2 ) couplings between C(sp 2 )–F bonds and corresponding C(sp 3 )–H bonds adjacent to heteroatoms proceeded smoothly to afford the desired products in moderate to good yields. Preliminary mechanistic investigations on this novel transformation revealed that the C–H cleavage process might be involved in the rate-determining step.
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Wang et al. (2019) studied this question.
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