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We report here that oligodeoxyribonucleotides which contain 5-bromouracil (Br^5U) and 5-methylcytosine (m^5C) bind duplex DNA at the same homopurine target sequence as their T/C analogues but with greater affinities and over an extended pH range. Oligonucleotides containing uracil (U) bind with lower affinity (Figure 1).
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Povsic et al. (1989) studied this question.
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