Why the study?
Does voluntary exercise alter transient outward K+ current and electrical remodeling in female rat hearts?
Population
69 female Sprague-Dawley rats, weight and age matched
Comparison
6 weeks of voluntary wheel running exercise vs Sedentary controls housed as standard laboratory…
Design
Preclinical, assigned randomly
Follow-up
6 weeks
Authors
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Animal data link voluntary exercise to repolarization remodeling in female rats; leaves open human arrhythmia relevance.
Does voluntary exercise alter transient outward K+ current and electrical remodeling in female rat hearts?
Voluntary exercise induces electrical remodeling in the rat heart by decreasing epicardial transient outward K+ current, which reduces the transmural action potential duration gradient.
Stones et al. (2009) studied this question.
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