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The bioequivalence of three sustained release nifedipine formulations designed in this laboratory, was assayed in rabbits by comparing their plasma time profiles to a reference (AdalatR retard).The analysis of data was performed by using the statistical moments as a measure of drug release. Results show a slowler absorption rate in the experimental formulations than in AdalatR retard, and not differences in the absorption extent.The composed one-compartment model, described for humans, showed to be also succesfull for rabbits.
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Remuñán et al. (1992) studied this question.
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