Answers are grounded in this paper and cite their sources.
A novel nonsteroidal androgen receptor antagonist, (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)benzonitrile (1), for the topical control of sebum production is reported. This compound, which is potent, selective, and efficacious in the clinically validated golden Syrian hamster ear animal model, was designed to be delivered to the pilosebaceous unit, the site of action, preferentially by the follicular route.
No takes yet. Share an insight, caveat, or question.
Mitchell et al. (2010) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: