September 21, 2012Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Endogenous IRAK-M Attenuates Postinfarction Remodeling Through Effects on Macrophages and Fibroblasts

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Why the study?

Does IRAK-M deficiency worsen postinfarction remodeling and systolic dysfunction in a mouse model of myocardial infarction?

Population

Wild-type and IRAK-M(-/-) mice with induced myocardial infarction, and murine cardiac fibroblasts in vitro

Comparison

IRAK-M knockout (IRAK-M(-/-)) vs Wild-type mice

Design

Preclinical

Authors

WCWei ChenChinese Academy of Medical Sciences & Peking Union Medical College ASAmit SaxenaCenters for Disease Control and Prevention NLNa LiElectrophysiology

Discussion

Member takes

Implication

IRAK-M may limit adverse post-MI remodeling in mice; leaves open its relevance as a therapeutic target in human heart failure.

Structured PICO

Does IRAK-M deficiency worsen postinfarction remodeling and systolic dysfunction in a mouse model of myocardial infarction?

Population

Wild-type and IRAK-M(-/-) mice with induced myocardial infarction, and murine cardiac fibroblasts in vitro

Intervention

IRAK-M knockout (IRAK-M(-/-))

Comparator

Wild-type mice

Outcome

Postinfarction remodeling and systolic dysfunctionsurrogate

Endogenous IRAK-M protects against adverse postinfarction remodeling by suppressing leukocyte inflammatory activity and inhibiting fibroblast-mediated matrix degradation.

Cite This Study

Chen et al. (2012) studied this question.

synapsesocial.com/papers/6a7e52bc37c44f9ef44f9d8b https://doi.org/10.1161/atvbaha.112.300310

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Bookmark

Endogenous IRAK-M Attenuates Postinfarction Remodeling Through Effects on Macrophages and Fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endogenous IRAK-M Attenuates Postinfarction Remodeling Through Effects on Macrophages and Fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider