Why the study?
Advances in imaging and genetics have shown that arrhythmogenic cardiomyopathy comprises multiple phenotypes dependent on genetic or acquired factors, requiring an updated summary on identifying the phenotype and its underlying causes.
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May inform phenotype-specific management in arrhythmogenic cardiomyopathy; leaves open prospective validation of personalized strategies.
Arrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In this study, the authors summarise the approach to the identification of the AC phenotype and its underlying causes. They believe that AC represents a paradigm for personalised medicine in cardiology and that better stratification of the disease will enhance the development of mechanism-based treatments.
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Alexandros Protonotarios (2020) studied this question.
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