Why the study?
Supplemental O2 therapy in preterm infants impairs lung development, but its impact on long-term systemic vascular structure and function has not been well explored.
Does neonatal hyperoxia exposure induce long-term structural and functional alterations in the systemic vasculature and left ventricular function in newborn Sprague-Dawley rats?
Population
Newborn Sprague-Dawley rats
Comparison
Hyperoxia (85% O2) vs normoxia (21% O2)
Design
Preclinical animal study
Authors
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May warrant caution with neonatal oxygen in preterms; hypothesis-generating in rats and leaves open human translation.
Does neonatal hyperoxia exposure induce long-term structural and functional alterations in the systemic vasculature and left ventricular function in newborn Sprague-Dawley rats?
Neonatal hyperoxia induces early and sustained aortic stiffness, vascular remodeling, and left ventricular dysfunction in a rat model, highlighting a potential mechanism for long-term cardiovascular risk in preterm infants receiving oxygen therapy.
Benny et al. (2020) studied this question.
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