RECENT experiments (1,2) have shown that uninephrectomized rats, given 1% sodium chloride to drink develop hypertension and widespread vascular disease following adrenal-enucleation. The rise in blood pressure occurs as the adrenal cortex regenerates from the capsule and cortical cells adherent to the capsule (3–7) which remain in situ following the operative procedure, and, hence, has been designated “adrenalregeneration hypertension.” The initial observations were made on young rats, and since Timiras, Faribault and Selye (8) have shown that the hypertensive and vasculotoxic actions of desoxycorticosterone acetate were particularly severe in young animals, the present experiment was performed to study the influence of age on the development of adrenal-regeneration hypertension and the accompanying morphologic lesions.
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Skelton et al. (1956) studied this question.