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Malaria remains a global health challenge, disproportionately affecting vulnerable populations in developing regions. The increasing resistance of Plasmodium species to conventional antimalarial drugs necessitates the exploration of alternative approaches. Phytochemicals, bioactive compounds derived from plants, have shown significant potential in combating malaria through their antiparasitic, insecticidal, and immune-modulating properties. This paper examines the role of various classes of phytochemicals, such as alkaloids, flavonoids, and terpenes, in malaria prevention. It also highlights traditional herbal remedies, innovative nanotechnology-based drug delivery systems, and the challenges in developing phytochemical-based antimalarial treatments. With continued research and interdisciplinary collaboration, phytochemicals could contribute to novel, cost-effective, and sustainable malaria control strategies.
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