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January 15, 2020Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsOpen Access

Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature

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Why the study?

Placental vascular homeostasis preserves perinatal and offspring health, but the role of cord blood-derived HDLs—which differ biologically from adult HDLs—in regulating placental vascular function was unknown.

Population

Cord blood-derived HDLs, feto-placental endothelium, and isolated placental chorionic arteries

Comparison

Neonatal HDL-S1P complex exposure

Design

Preclinical laboratory study

Authors

IGIlaria Del GaudioInsermISIvana SreckovicMedical University of GrazPZPablo Zardoya-LaguardiaMedical University of Graz

Discussion

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Overview

Hypothesis-generating for nHDL-S1P placental protection; requires human studies before clinical consideration.

Structured PICO

P
Population
Feto-placental endothelium and isolated placental chorionic arteries (preclinical model using cord blood-derived HDLs)
I
Intervention
Neonatal HDL (nHDL) and its S1P complex
O
Outcome
Placental endothelial barrier function and vasorelaxationsurrogate

Circulating neonatal HDL exerts vasoprotective effects on the feto-placental endothelial barrier primarily via S1P signaling, which may be crucial for preserving placental vascular homeostasis.

Cite This Study

Gaudio et al. (2020) studied this question.

synapsesocial.com/papers/6a7e6ca2280ff5a364b7b63ehttps://doi.org/10.1016/j.bbalip.2020.158632
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Also Consider

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  3. 3Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia2016 · 337 citations
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