This review summarizes the structural mechanisms by which ribosomal proteins recognize and stabilize specific spatial architectures of ribosomal RNA in bacterial ribosomes.
May inform ribosome-targeted antibiotic design; leaves open in vivo validation of unstructured protein roles.
This review is focused on the structural aspects of interaction between ribosomal proteins and ribosomal RNA in bacterial ribosomes and complexes of ribosomal proteins with specific fragments of ribosomal RNA. Special attention is given to the recognition of specific spatial architecture of the double-stranded ribosomal RNA by ribosomal proteins and to the role of unstructured protein regions in stabilization of distant ribosomal RNA segments.
No takes yet. Share an insight, caveat, or question.
А.Д. Никулин (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: