When reported in 2000, gene therapy for X-linked severe combined immune deficiency (SCID-X1) represented a first clear success in clinical gene therapy, providing a tremendous boost for the field. Retroviral gene transfer of the common cytokine receptor γ-chain, required for the function of multiple cytokine receptors, to bone marrow–derived hematopoietic stem and progenitor cells reconstituted development of functional T cells and thereby also partially restored the ability of the affected boys to mount proper B-cell responses.
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Roland W. Herzog (2010) studied this question.